Sulbutiamine is a nootropic that has mildly stimulating and mood-boosting qualities.  It is a synthetic derivative of vitamin B¹, more commonly known as thiamine.  Sulbutiamine is able to cross the blood-brain-barrier easier than thiamine, making it much more effective[1].  

First developed in Japan, Sulbutiamine has been used to treat a number of conditions.  Some of these include Chronic Fatigue Syndrome[2], asthenia[3], and erectile dysfunction[4].


As a nootropic, Sulbutiamine is used to improve memory and focus.  Many users report that it has a mildly stimulating quality to it.  It is rarely used by itself.  Rather, it is used as part of a stack with other nootropics.  Sulbutiamine is sold as a dietary supplement in the United States and is legal to possess without a prescription.

What are some of the benefits of Sulbutiamine?

  • ⇒ Increased Focus
  • ⇒ Mildly Stimulating
  • ⇒ Improved Mood
  • ⇒ Improved Concentration
  • ⇒ Stacks Well With Other Nootropics

How does it work?sulbutiamine-link

Like all nootropics, the exact way that Sulbutiamine works is not totally understood.  It is known that Sulbutiamine crosses the blood-brain-barrier much more efficiently than thiamine[1].  Sulbutiamine is thought to cause upregulation in the reticular activating system, which is a part of the brain known to play a large role in motivation and arousal[5].  It is also known to have an effect on the cholinergic, dopaminergic, and glutamatergic neurotransmitter systems.  It is believed to have its nootropic effects through these mechanisms.

Safety/Side effects

Sulbutiamine is generally considered to be safe when taken at the recommended dosages.  However, some people have experienced mild side effects that usually go away after Sulbutiamine is discontinued.  These uncommon side effects may include headaches, skin rash, depression/anxiety, nausea, and irritability, especially in the elderly.  As with all supplements, you should always consult a physician before starting anything new.  You should not use Sulbutiamine if you are pregnant or breast feeding.


The recommended dosage for Sulbutiamine is 400-1000mg.  It is always a good idea to start with the lowest dose and work your way up as need.  Sulbutiamine is often used with other nootropics as part of a stack.  When stacking nootropics it is even more important to start with low doses, as many nootropics increase the effectiveness of each other.


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[1]  Bettendorff L, Weekers L, Wins P, Schoffeniels E (1990). “Injection of sulbutiamine induces an increase in thiamine triphosphate in rat tissues”. Biochem Pharmacol 40 (11): 2557–60.

[2]   Layzer RB (1998). “Asthenia and the chronic fatigue syndrome”. Muscle Nerve 21 (12): 1609–11.

[3]  Shah SN; Sulbutiamine Study Group (2003). “Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia”. J Assoc Physicians India 51: 891–5.

[4]  Dmitriev DG, Gamidov SI, Permiakova OV (2005). “[Clinical efficacy of the drug enerion (sulbutiamine) in the treatment of patients with psychogenic (functional) erectile dysfunction]”. Urologiia 1 (1): 32–5.

[5]  Van Reeth O (1999). “Pharmacologic and therapeutic features of sulbutiamine”.Drugs Today (Barc) 35 (3): 187–92.