What Is The Strongest Nootropic?

What Is The Strongest Nootropic?

One of the questions that we get asked all the time is “What is the strongest nootropic?”

While this is a pretty straight-forward question, unfortunately there is no straight-forward answer. There are just too many different factors that need to be taken into consideration.

But we’re gonna look at those different factors, and explore what some of the potential contenders for strongest nootropic could be.

What Makes A Nootropic Strong?

The first problem that we run into is the definition of strong. Actually, the first problem is the definition of nootropic.

Some definitions of “nootropic” include drugs like Adderall and Phenibut, because they can have a positive effect on cognitive performance. But other definitions exclude them, because of their potential for misuse and withdrawal.

strongest nootropic
What is the strongest nootropic? Unfortunately, this question doesn’t have a simple answer.

So this is an obvious problem. If we include Adderall, for example, it would surely be high up on the list of the strongest nootropics. But by many definitions, it is not a true nootropic because tolerance develops quickly and there is a high potential for abuse.

And what makes a nootropic “strong?” How it makes you feel? How long the effects last? How quickly it kicks in? How small a dosage you can use and get results?

See the problem here? There are a number of different ways that we can define “strong” in this situation. And each definition would give us a different answer.

Because of this, it would be impossible to label any single nootropic as the strongest nootropic.

Another problem that we run into is the fact that each nootropic affects everyone differently. What you consider to be the strongest nootropic might be considered very weak to someone else.

Everyone’s brain chemistry is different. There is so much variation from person to person that each nootropic affects each person differently.

For all these reasons, there is really no correct answer to the question, “What is the strongest nootropic?”

However, while we can’t pinpoint the strongest nootropic, we can certainly talk about what some strong nootropics are. Let’s look at some strong nootropics, and what it is about them that makes them so strong.


By all definitions, this is a strong nootropic. Phenylpiracetam has been reported to increase focus, motivation, and memory, while improving mood and physical performance.

It does all this without causing dependence or withdrawal. Phenylpiracetam has been extensively studied and has an excellent safety profile.

While it is available in the United States without a prescription, phenylpiracetam is only available with a prescription in other parts of the world. In Russia, for example, it is a prescription drug sold under the brand name Phenotropil.

This nootropic is so strong that it’s actually banned from sports by the World Anti-Doping Agency (WADA). If you participate in a professional sport and have to undergo drug testing, you should not take phenylpiracetam.

phenylpiracetamPhenylpiracetam Benefits:

  • Increased Focus
  • Improved Mood
  • Improved Memory
  • Increased Alertness
  • Increased Motivation
  • Increased Ability To Learn
  • Improved Physical Performance
  • Reduced Sensitivity To Extreme Temperatures

How to take: Phenylpiracetam is usually taken in dosages of 100-300 milligrams, one to three times a day (for a total of 200-600 mg/day). For maximum absorption, take on an empty stomach. If nausea and upset stomach occurs, you should try taking with food. To boost effectiveness and reduce potential for side-effects, take phenylpiracetam with a choline source, like Alpha-GPC.

Side-effects: Phenylpiracetam is generally very well-tolerated. Side-effects are rare and may include headache, nausea, upset stomach, insomnia, agitation, and nervousness. Taking a choline source with phenylpiracetam may reduce or eliminate some of the side-effects.

If you want to learn more about phenylpiracetam, read this.


This is another nootropic that many users consider to be strong. Adrafinil is a prodrug of modafinil. A prodrug is a drug that converts into another drug once it is in the body. Adrafinil converts into modafinil, which is a potent wakefulness-promoting drug.

Modafinil is the generic name of the popular prescription drug, Provigil. Adrafinil converts into this once it is in the body.

Modafinil is only available in the United States with a prescription. Adrafinil, however, is available legally without a prescription. It is affordable, available, and effective. For these reasons, we’re listing it as one of the strongest nootropics.

Adrafinil is in a class of drugs known as eugeroics. These are wakefulness-promoting agents. They increase wakefulness, and improve focus, memory, and motivation.

adrafinilAdrafinil Benefits:

  • Increased Focus
  • Increased Alertness
  • Increased Productivity
  • Increased Motivation
  • Increased Wakefulness

How to take: The standard adrafinil dosage is reported to be between 600-1200 milligrams, taken in one or two doses. It should not be taken late in the day, as this may cause insomnia. For maximum absorption, take adrafinil on an empty stomach. If nausea or upset stomach occurs, you should take adrafinil with food.

Side-effects: Adrafinil is well-tolerated by most people. Side-effects are uncommon and may include headache, nausea, upset stomach, insomnia, nervousness, and anxiety. Taking adrafinil with food may reduce or eliminate some of these side-effects.

If you would like to learn more about adrafinil, read this.


We almost left this one off this list. Not because it doesn’t have nootropic benefits. And certainly not because it isn’t strong.

But because phenibut doesn’t meet the criteria for nootropic. Not in the strictest sense, anyway. With phenibut, tolerance develops quickly and it can cause withdrawal if taken too frequently. By many definitions of nootropic, this disqualifies phenibut from being considered a true nootropic.

However, we’ve decided to list it here because, when taken responsibly, phenibut can have a number of powerful nootropic benefits.

phenibutPhenibut Benefits:

  • Reduced Anxiety
  • Reduced Stress
  • Improved Sleep
  • Improved Mood
  • Relaxation
  • Reduced Social Anxiety

How to take: The recommended dosage is between 300-1000 milligrams. Effects may take several hours to feel. Do not re-dose. Phenibut should not be taken more than twice per week, and it should not be taken on consecutive days. Tolerance develops quickly. Taking phenibut more than twice a week dramatically increases the possibility of side-effects. Taking phenibut on an empty stomach may increase its effectiveness. Do not drive or operate machinery until you know how it affects you. Again, do not take phenibut more than twice a week.

Side-effects: Side-effects, at recommended dosages, are uncommon and may include tiredness, nausea, upset stomach, sedation, dizziness, somnolence, and talkativeness. Serious side-effects may occur with daily use or excessively-high dosages. One last time: Do not take phenibut more than twice a week.

To learn more about phenibut, read this.


As you have seen, there is no easy way to answer the question, “What is the strongest nootropic?” But we have looked at three strong nootropics, their benefits, side-effects, and typical dosages.

A different way of asking what the strongest nootropic is would be to ask what the best nootropic is to get a particular effect. That’s why we’ve created our “Best Nootropic For…” series.

You can check out our Best Nootropics For… series in the sidebar on the right, or by clicking here.

What Is The Strongest Nootropic?
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