Coluracetam is a nootropic that has been getting a lot of attention from the medical community and from nootropics users. This is a supplement that is likely to become very popular in the coming years.

Of all the nootropics that are available today, this is one of the newer ones. It was created in 2005 by the Japanese pharmaceutical company Mitsubishi Tanabe. They first synthesized it by modifying the well known nootropic, piracetam. The patent for this unique compound was transferred to the company BrainCells, Inc. They are a company that provides drugs to treat central nervous system diseases.

BrainCells, Inc. are currently conducting clinical testing for coluracetam. So far, the research has been very promising. Coluracetam shows great potential to treat certain central nervous system disorders as well as optic nerve and retinal damage.

Coluracetam Effects

Depression and Anxiety

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Coluracetam shows a lot of promise as a potential treatment for depression and anxiety. In clinical trials, researchers found that taking 80mg of coluracetam three times a day reduced symptoms of depression with co-morbid generalized anxiety disorder.

There are a lot of anecdotal reports around the internet of people using coluracetam to treat the symptoms of depression and anxiety. Users typically report a reduction in anxiety and either the reduction or elimination of depressive symptoms. More research is needed in this area. But initial research is very promising.

Memory and Learning

Like other drugs in the same family as coluracetam, many users report improvement in memory and learning. One study done on rats showed that coluracetam improved memory for up to 72 hours after administration.

Of course, this does not mean that it will have the exact same effect on humans. Experiments are conducted on rats because their chemistry is similar enough to ours that we can learn a lot from it. Anecdotal reports from around the internet do seem to validate these findings, though.

Users of coluracetam describe similar cognitive benefits to powerful nootropics like phenylpiracetam and sunifiram. These benefits include improved memory (storage and recall), increased learning, and more focus without stimulation.


Research done on coluracetam shows that it is beneficial to the treatment of optic nerve and retinal injuries. Coluracetam may have other eye benefits like improved vision and increased visual recognition.

Users often report clearer vision. Colors are a little brighter and things seem to be more focused and three dimensional.

Coluracetam Side Effects

Coluracetam has only been studied in humans a little bit. Much more research is necessary before it can be said that it is completely safe.

However, in the studies that have been done, it has been shown to be safe. Researchers reported that after a daily coluracetam dose of 240 mg per day in clinical trials, no one had any side effects. The coluracetam dosage was divided into three equal doses. This is the highest dose that has been studied and shown to be safe, so far.

Coluracetam Stack

Many users add coluracetam as part of a stack. “Stacking” is simply taking 2 or more nootropics together to increase their effectiveness.

The most common coluracetam stack consists of taking coluracetam with a choline source, like Alpha-GPC. This is common practice with other drugs in the same class, the racetams. Adding a choline source helps to increase the benefits and reduce the chances of potential side effects, like headaches.

Other users add other nootropics with mood-boosting and anxiety-reducing effects. They have found that adding aniracetam or Noopept to a coluracetam stack will increase its effectiveness.

No negative interactions have been reported by stacking coluracetam with other nootropics. However, drug interactions could potentially occur, although unlikely. We always recommend you talk to you doctor before taking any new supplements.

How Does Coluracetam Work?

Coluracetam works by affecting certain chemicals in the brain, called neurotransmitters. One of the main neurotransmitters that coluracetam affects is acetylcholine. Like other drugs in its class, coluracetam elevates the body’s choline uptake. It interacts with the high affinity choline uptake process, which is the way the body absorbs choline into neurons.

Research also shows that coluracetam improves AMPA potentiation. This is a glutamate receptor that helps with synaptic transmission in the central nervous system. It is known to play a crucial role in alertness and other cognitive functions.

Coluracetam Dosage

coluracetam check it outThe recommended starting coluracetam dosage is between 5 and 35 mg. Some people report great results with a low dose. Always start low and work your way up as needed.

The highest coluracetam dosage used in clinical trials was 80 mg three times a day. In that study, no side effects were reported at that dose.

You should always start low and work your way up as needed. And it is recommended that you take a choline source with coluracetam, like Alpha-GPC. This will increase it’s effects and reduce the chances of potential side effects, like headahces.

Where To Buy Coluracetam

As this is a relatively new nootropic, there are not a lot of suppliers that carry it, yet. I highly recommend you get it from Peak Nootropics. I’ve been ordering from them for years and have never been disappointed. They have high-quality products, fast shipping, and competitive prices.

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